The clinical and cost effectiveness of surgical interventions for stones in the lower pole of the kidney: The Percutaneous nephrolithotomy, flexible Ureterorenoscopy and Extracorporeal shockwave lithotripsy for lower pole kidney stones Randomised Controlled Trial (PUrE RCT)
Study area: Surgical
Aim: To find which of the three standard surgical treatments for removal of lower pole kidney stones is most clinically and cost effective, dependant on the size of the kidney stone.
Who can participate: Men and women aged over 16 with a stone (or stones) in the lower pole of either kidney.
A randomised double-blind controlled phase III study to compare the efficacy and safety of intravenous ferric carboxymaltose with placebo in patients with anaemia undergoing major open abdominal surgery
Study Area: Surgical
Aim: To determine if a single dose of intravenous iron administered to patients with anaemia prior to major surgery reduces the need for peri-operative blood transfusion. Also to evaluate the effect of intravenous ferric iron compared with placebo on health related quality of life, post-operative morbidity, safety and length of hospital stay
Who can participate: Men and women aged over 18 who are planned for an elective open abdominal surgery and have been found to be anaemic (Haemoglobin blood test result between 130-90 g/L for men and 120-90 g/L for women).
Chronic Constipation treatment of surgical treatment for adults
Study area: Surgery
Aim: Primary aim to determine the efficacy of laparoscopic ventral mesh rectopexy compared to controls at short term follow up (24 week post-surgery).
Secondary aim is to determine the effectiveness of laparoscopic ventral mesh rectopexy and pre-operative determinants of outcome in the medium term (48-72 weeks).
Who can participate: Adults 18-70 years with chronic constipation with self reported symptom duration >6 months, failure with laxatives and lifestyle modifications, failure of previous nurse led conservative therapies. Surgically correctable pelvic floor abnormalities.