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Burns and Plastics Studies

Nail bed INJury Analysis: Should the nail plate be replaced or discarded after nail bed repair in children?

Study area = Plastics

Aim = Over 10,000 children undergo surgery to repair a cut in the nail bed in the UK every year. During surgery, the nail is taken off and the cut stitched up. The nail can either be put back on, or thrown away.

We will assess the two options in a research study called a randomised controlled trial. It will enable a fair and reliable comparison of the two options.  We will look at impact of the two options on cosmetic appearance, occurrence of an infection, pain, and subsequent healthcare use.

Who can participate = Children under 16 who have a nail bed injury that requires surgical repair


The Cleft Collective

Study area: Burns and Plastics / Midwifery

Aim: The aim of The Cleft collective study is to try and understand more about the role that the environment and genetics play in the development of a cleft; about which treatments work best, when and for whom; and about how the parents and the child adapt to the cleft and it’s treatment.

Who can participate: For the Birth Cohort, all children diagnosed (antenatally or postnatally) with a cleft during the period 01/04/2013 – 31/03/2018 and their families will be eligible to participate. For those children diagnosed with a cleft antenatally Mothers and partners will also be asked to consent to the collection of cord blood after birth.For the Five-year-old Cohort, all children born with a cleft between 01/04/2008 – 31/03/12 and their parents will be eligible to participate.

All families will be eligible regardless of cleft type or the presence of additional conditions/syndromes. For the 5 year cohort, all children diagnosed.

The Cleft Collective Speech and Language Study (LENA)

Study area: Burns and Plastics

Aim:The aim of The Speech and Language study is to find out more about how speech and language develops in children who are born with cleft palate and to identify which factors are most helpful in promoting speech and language development for these children. The study is asking families to record their baby’s speech over the course of a day, using specially designed recording devices.

Who can participate:All families who are participating in the Cleft Collective Birth Cohort study are being invited to participate in this study up until the child’s age of 13 months.

Molecular mechanisms and pathways of chronic inflammatory and degenerative diseases. (Dupuytren’s patients)

Study area: Burns and Plastics 

Aim: The aim of the study is to gain a greater understanding of the development and triggers of inflammatory diseases such as Dupuytrens Disease at the molecular and genetic level. By patients donating diseased tissue we can find out new ways of treating these disorders and use advanced technology to learn more about the Dupuytrens disease. 

Who can participate: Any Patients undergoing surgical intervention for diagnosed Dupuytrens disease.

Sifti-2, A multicentre, prospective study to examine the relationship between neutrophil function and sepsis in adults and children with severe thermal injuries.

Study area = Burns

Aim = The aim of this study is to look in depth at what happens after the body sustains a large burn. We know that after a burn some people develop an infection. We would like to examine in detail what happens to our body before an infection occurs, during and after.

Who can participate = Children with a burn covering more than 15% total body surface area and adults with a burn covering more than 20% total body surface area

If you would like any further information on the following studies, and to find out if you are eligible please contact:


Address: R&D office, C254, West Wing, Broomfield Hospital, Court Road, Chelmsford, Essex, CM1 7ET

Telephone: 01245 515136
Email: Research@meht.nhs.uk